SYNTHESIS OF IONIC LIQUIDS AND THEIR IN-VIVO AND IN-VITRO TOXICOLOGICAL ASSA
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Date
2023-06-15
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DEPARTMENT OF ZOOLOGY KINNAIRD COLLEGE FOR WOMEN UNIVERSITY LAHORE,
Abstract
Deep eutectic solvents belong to the class of ionic liquids. They are called as “Designer
solvents” because we can mold or change them according to our requirements. The synthesis
of Ionic liquid (ILs) and them in-vivo and in-vitro toxicological activities were the main goals
of this study. An ammonium-based salt tetrahexyl ammonium bromide (THAB) was taken as
a hydrogen bond acceptor and decanoic acid (DA) was taken as a hydrogen bond donor to
synthesize deep eutectic solvent. Both components were heated at 80oC for 2 hours. A
homogenous solution was obtained which was labelled as S13. The pure and diluted form of
solvent was applied to bacteria, fungi and fish to test its toxicity. The solvent shows both
positive and negative toxic effects on test organisms. In bacteria 10-3 didn’t show any zone of
inhibition on S.aureus and in E.coli on 10-2 it didn’t show any zone of inhibition. DES was
applied to pre cultured plates of A.niger an inhibition ring showed up after incubation and zero
inhibition on cultured plates of A.niger. In full test in fishes, all dilutions except 10-5 resulted
in mortalities