WOUND HEALING AND ANTIFUNGAL PROPERTIES OF LEMON GRASS
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Date
2023-06-15
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DEPARTMENT OF ZOOLOGY KINNAIRD COLLEGE FOR WOMEN UNIVERSITY LAHORE,
Abstract
Medicinal Plants have the potential to heal wounds. Lemon grass is one of several
plants that have antifungal and wound healing properties. The purpose of this study is
to confirm the antifungal and wound healing properties of lemon grass extracts in
albino rats with acid-burned injuries. The antifungal potential of lemon grass extracts
(20 µl and 40 µl) on Candida albicans showed remarkable positive results by
indicating the inhibition zone. Lemon grass extracts demonstrated best antifungal
results at 20 µl. At 40 µl, it also showed excellent antifungal results. The wound
healing potential of lemon grass extracts was estimated using the wound index
measurement, antioxidant estimation, sandwich enzyme-linked immunosorbent assay
(ELISA), and histological test. The results obtained were highly significant. Lemon
grass demonstrated remarkable wound contraction potential by increasing vascular
endothelial growth factor (VEGF) level at different doses (50 and 100 mg/ml). Lemon
grass extracts demonstrated the greatest wound healing potential at 100 mg/ml (the
VEGF marker increased, while apoptosis decreased) whereas at 50 mg/ml it also
demonstrated great wound healing ability. In addition, the histopathological tests also
confirmed the wound healing potential of lemon grass extracts. Based on the above
results, the extraction, recognition, and purification of phytochemicals from lemon
grass extracts is strongly recommended as a viable extension for future research.