EVALUATION OF SKIN REGENERATION & ANTIBACTERIAL PROPERTIES OF LEMON PEEL
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Date
2023-06-15
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DEPARTMENT OF ZOOLOGY KINNAIRD COLLEGE FOR WOMEN UNIVERSITY LAHORE,
Abstract
Medicinal plants are believed to have wound healing abilities and are found to be very
effective in antibacterial, antiviral, and anticancer activities. One of these plants with
curative properties is the lemon. This study aims to evaluate the antibacterial and skin
regeneration potential of lemon peel using two E. coli strains and albino rats. The
extract in different concentrations of 20 µl and 40 µl was tested against DH5 alpha and
BL21 strains, and clear inhibitory zones were observed in both groups. For in vivo
investigations, the wound index measurements, sandwich ELISA, antioxidant assays,
and histopathological tests of rats were conducted. The two groups of rats were given
extracts at doses of 50 mg/ml and 100 mg/ml, and the results were compared to those
of injured or untreated rats, which showed wound healing with high levels of VEGF in
the treated groups, especially in the group with dose 100 mg/ml. Antioxidant values
were found to be highly significant. And the histopathology of skin samples revealed
that the skin of treated rats is healing effectively and is almost back to normal. These
findings indicate that lemon peel could be very efficient for the treatment of burn
wounds and bacterial infections.